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Pathogenesis

The tangled path of amyloid and tau

The amyloid cascade hypothesis has been the workhouse of Alzheimer’s research for 25 years. But the disease’s devilish complexity is only now becoming clear – Alzheimer’s dementia is not the result of a single aberrant protein, but seems to arise from a tangled network of dysregulated pathways. Which are primary among them – and how to effectively treat them – remain mysteries.